Does the Paleo diet affect an athlete's health and sport performance?

The aim of the study was to assess the impact of an eight-week Paleo diet on the health status (body composition, haematology and biochemistry of blood and urine) and the level of physical capacity (aerobic and anaerobic) of professional handball players. Fifteen athletes were assigned to two groups: 9 in the experimental group (PD) and 6 in the control group (CD). Significant decreases in body mass (BM), body mass index (BMI), and fat mass (FM) as well as an increase in the fat-free mass (FFM) (%) in both groups were observed. There were no significant differences between groups in particular series during the experiment in all haematological and biochemical indicators of blood and urine. Only HDL-C was significantly higher in the last series in the PD compared to the CD (1.63 mmol/l vs. 1.23 mmol/l). In the Wingate test, there were only single intragroup changes, consisting of a significant decrease in the Wt, MAP and Pmean in the experimental group. There were no significant differences between the groups in individual series or intragroup differences during the experiment, determined by the VO2max, VEmax, VE ∙ VCO2 -1, RER, and the time of the test with a gradually increasing load on a treadmill, except for a significant decrease of maximum tidal volume (TVmax) in the PD. No adverse effect of the Paleo diet on the health status was found. The use of the Paleo diet slightly adversely affects anaerobic capacity and does not affect the level of aerobic capacity.

Impact of Paleo Diet on Body Composition, Carbohydrate and Fat Metabolism of Professional Handball Players.

The Paleo diet (PD) involves a restriction of carbohydrates and increased fat content (35% energy from carbohydrates, 35% energy from fats and 30% energy from protein). The aim of this study was to examine the effect of the PD on body composition, concentration of carbohydrates and lipids, as well as insulin, irisin, adiponectin and leptin in the blood. A total of 25 handball players were assigned to two groups: 14 in the experimental group (PD) and 11 in the control group (CD), using a PD and a rational diet, respectively. Analysis of body mass and body composition (body mass index, fat mass, lean body mass, fat-free mass, muscle mass, bone mineral content and bone mineral density), as well as blood concentration of metabolism markers (glucose, insulin, total cholesterol, HDL-cholesterol, non-HDL-cholesterol, LDL-cholesterol, triglycerides, free fatty acids, ß-hydroxybutyrate, irisin, adiponectin and leptin), were determined at the beginning and after 4 and 8 weeks of nutritional intervention. Body mass was lower (p < 0.01), and adiponectin blood concentration was higher (p = 0.03) in the PD group at the end of the intervention. There were no changes (p ≥ 0.05) in body composition and blood levels of other biochemical markers in either group.

Effects of Antidepressant Treatment on Neurotrophic Factors (BDNF and IGF-1) in Patients with Major Depressive Disorder (MDD).

Major depressive disorder (MDD) remains the subject of ongoing research as a multifactorial disease and a serious public health problem. There is a growing body of literature focusing on the role of neurotrophic factors in pathophysiology of MDD. A neurotrophic hypothesis of depression proposes that abnormalities of neurotrophins serum levels lead to neuronal atrophy and decreased neurogenesis, resulting in mood disorders. Consequently, in accordance with recent findings, antidepressant treatment modifies the serum levels of neurotrophins and thus leads to a clinical improvement of MDD. The purpose of this review is to summarize the available data on the effects of various antidepressants on serum levels of neurotrophins such as brain-derived neurotrophic factor (BDNF) and insulin-like growth factor (IGF-1). In addition, the authors discuss their role as prognostic factors for treatment response in MDD. A literature search was performed using the PubMed database. Following the inclusion and exclusion criteria, nine original articles and three meta-analyses were selected. The vast majority of studies have confirmed the effect of antidepressants on BDNF levels. Research on IGF-1 is limited and insufficient to describe the correlation between different antidepressant drugs and factor serum levels; however, four studies indicated a decrease in IGF-1 after treatment. Preliminary data suggest BDNF as a promising predictor of treatment response in MDD patients. The role of IGF-1 needs further investigation.

Paleolithic Diet-Effect on the Health Status and Performance of Athletes?

The aim of this meta-analysis was to review the impact of a Paleolithic diet (PD) on selected health indicators (body composition, lipid profile, blood pressure, and carbohydrate metabolism) in the short and long term of nutrition intervention in healthy and unhealthy adults. A systematic review of randomized controlled trials of 21 full-text original human studies was conducted. Both the PD and a variety of healthy diets (control diets (CDs)) caused reduction in anthropometric parameters, both in the short and long term. For many indicators, such as weight (body mass (BM)), body mass index (BMI), and waist circumference (WC), impact was stronger and especially found in the short term. All diets caused a decrease in total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG), albeit the impact of PD was stronger. Among long-term studies, only PD cased a decline in TC and LDL-C. Impact on blood pressure was observed mainly in the short term. PD caused a decrease in fasting plasma (fP) glucose, fP insulin, and homeostasis model assessment of insulin resistance (HOMA-IR) and glycated hemoglobin (HbA1c) in the short run, contrary to CD. In the long term, only PD caused a decrease in fP glucose and fP insulin. Lower positive impact of PD on performance was observed in the group without exercise. Positive effects of the PD on health and the lack of experiments among professional athletes require longer-term interventions to determine the effect of the Paleo diet on athletic performance.

Effects of Antidepressant Treatment on Peripheral Biomarkers in Patients with Major Depressive Disorder (MDD).

Major depressive disorder (MDD) is one of the most prevalent mental illness and a leading cause of disability worldwide. Despite a range of effective treatments, more than 30% of patients do not achieve remission as a result of conventional therapy. In these circumstances the identification of novel drug targets and pathogenic factors becomes essential for selecting more efficacious and personalized treatment. Increasing evidence has implicated the role of inflammation in the pathophysiology of depression, revealing potential new pathways and treatment options. Moreover, convergent evidence indicates that MDD is related to disturbed neurogenesis and suggests a possible role of neurotrophic factors in recovery of function in patients. Although the influence of antidepressants on inflammatory cytokines balance was widely reported in various studies, the exact correlation between drugs used and specific cytokines and neurotrophins serum levels often remains inconsistent. Available data suggest anti-inflammatory properties of selective serotonin reuptake inhibitors (SSRIs), selective serotonin and noradrenaline inhibitors (SNRIs), and tricyclic antidepressants (TCAs) as a possible additional mechanism of reduction of depressive symptoms. In this review, we outline emerging data regarding the influence of different antidepressant drugs on a wide array of peripheral biomarkers such as interleukin (IL)-1ß, IL-2, IL-5, IL-6, IL-8, IL-10, C-reactive protein (CRP), or interferon (IFN)-γ. Presented results indicate anti-inflammatory effect for selected drugs or lack of such effect. Research in this field is insufficient to define the role of inflammatory markers as a predictor of treatment response in MDD.

Dietary mistakes of Polish athletes in relation to the frequency of consuming foods recommended in the Swiss food pyramid for active people

Background: Mistakes in dietary choices and an unbalanced diet reduce the exercise capacity of athletes. Nutritional behaviours are conditioned by environmental and individual factors. Objective: The aim of the study was to assess the scale of improper eating behaviours among high-performance Polish athletes depending on gender, sports level and type of discipline. Material and methods: The study was conducted among 610 athletes (391 men and 219 women). The group consisted of 289 athletes of individual disciplines and 321 team sports athletes representing the championship sports class (282 individuals) as well as the first and second classes (328 subjects). The authors' validated nutritional behaviour questionnaire was used, referring to the recommendation of the Swiss nutrition pyramid for athletes. In statistical analysis, the Chi2 test was applied (α=0.05). Results: Athletes most often demonstrated improper behaviours regarding: insufficient frequency of consuming vegetable fats (61.78%), fruits (59.89%), wholegrain products (59.90%), vegetables (53.62%) and dairy products (52.09%), and not limiting the intake of energy drinks (59.89%). Compared to women, men, to a larger extent, did not include the following in their daily diet: raw vegetables (p<0.001), wholegrain products (p<0.05) and vegetable fats (p<0.01). Significantly more often, they also did not limit the consumption of: animal fats (p<0.001), sweetened carbonated beverages (p<0.001), energy drinks (p<0.05) or fast food products (p<0.001). Women consumed meals less regularly (p<0.01), rarely ate fish (p<0.01), and were more likely to be inadequately hydrated (p<0.05). Athletes training individual sports disciplines compared to those training team sports consumed hydrating beverages (p<0.001) less often, but included fruit in their daily diet more frequently (p<0.05). Athletes from the master class consumed meals irregularly (p<0.01) in a smaller percentage than athletes with a lower sports class, not limiting animal fats (p<0.05) and implementing inadequate hydration (p<0.05). Conclusions: The scale of incorrect nutrition choices among athletes indicated variations depending on gender, sports level and type of sport practiced, with incorrect behaviours more often presented by men than women and competitors with a lower sports level (non-master class). The nature of the performed discipline was a factor less differentiating the nutritional choices of athletes.

Prevalence of the use of effective ergogenic aids among professional athletes.

BACKGROUND: Athletic performance can be substantially enhanced with supplements and functional food which are considered by scientists as efficient, safe and legal, such as protein, carbohydrate and protein-carbohydrate supplements, isotonic sports drinks, carbohydrate-protein bars, carbohydrate bars, creatine and caffeine. OBJECTIVE: The study is aimed at an analysis and evaluation of the prevalence of using effective ergogenic aids (creatine, caffeine, isotonic drinks, carbohydrates, and proteins) in a group of Polish professional athletes. MATERIAL AND METHODS: The research was conducted on 600 athletes (216 women, 384 men) practicing various sports disciplines; the younger group (18-23 years old) consisted of 307 people, while the older one (24-35 years old) was comprised of 293 subjects. A questionnaire was used with questions concerning the frequency and types of consumed supplements. RESULTS: Nearly half of the athletes (48,2%) admitted to taking supplementation, of which 36.7% consumed the supplements occasionally and 11.5% continually. The majority of the group (75.4%) claimed to be consuming isotonic drinks, which were the most commonly chosen nutritional aid enhancing physical performance, most frequently supplementing the diet in a continuous manner (41.2%). The least frequently used supplement was creatine, chosen by only one in three interviewees (34,5%). The ergogenic aids were used more often by men than women (50.5% vs. 44.1%), and so were nutrients based on proteins (51.8% vs. 32.0%), carbohydrates (60.7% vs. 46.8%), protein-carbohydrates (45.6% vs. 32.9%), as well as creatine (39.8% vs. 25.0%). The studies showed the inessential difference in the frequency of taking supplementation based on the interviewees' age (0.4%). CONCLUSIONS: Competitors who use supplements over those who choose not to, seems to reflect the continuous lack of the athletes' sufficient awareness of the effectiveness, safety, and health benefits of dietary supplementation that enhances physical performance. KEY WORDS: supplements, dietary supplementation, sport, performance-enhancing substances, athletes.